PATRICIA J. WITTKOPP (née Polaczyk)
1061 Natural Science Bldg.
830 N. University Ave.
University of Michigan
Ann Arbor, MI 48109-1048
Telephone: 734 / 763-1548
Fax: 734 / 763-0544
Email: wittkopp@umich.edu
Labpage: www.umich.edu/~pwlab
RESEARCH INTEREST: Understanding the genetic basis of development, evolution and disease, with an emphasis on the molecular mechanisms controlling gene expression
EDUCATION:
1997-2002 Ph.D. in Genetics
University of Wisconsin, Madison, WI
Advisor: Dr. Sean Carroll
2001 North Carolina State University Summer Institute in Statistical Genetics
Bioinformatics and Molecular Evolution Modules
1993-1997 B.S. in Cellular and Molecular Biology (with highest honors and distinction)
B.S. Chemistry (with distinction)
Highest Honors in Cellular and Molecular Biology
University of Michigan, Ann Arbor, MI
Advisor: Dr. Greg Gibson
ACADEMIC APPOINTMENTS:
2005-Assistant Professor of Ecology and Evolutionary Biology
Assistant Professor of Molecular, Cellular, and Developmental Biology
Member, Program in the Biomedical Sciences
Member, Center for Computational Medicine and Biology
Member, Center for Statistical Genetics
Trainer, NIH Genome Sciences Training Grant
Trainer, NIH Genetics Training Grant
University of Michigan, Ann Arbor, Michigan
2002-2005-Damon Runyon Cancer Research Foundation Postdoctoral Fellow
Cornell University, Ithaca, NY
Advisor: Dr. Andrew Clark
FELLOWSHIPS AND AWARDS:
2009 - Semi-finalist, Howard Hughes Medical Institute Early Career Award
2008 - “Scientist to Watch”, The Scientist
2008 - Institutional nominee for Packard Award
2008-2010 - Alfred P. Sloan Research Fellow
2007-2009 - March of Dimes Basil O’Connor Starter Scholar Research Award
2006 - Institutional nominee for Searle Scholar Award
2003-2006 - Damon Runyon Cancer Research Foundation Postdoctoral Fellow
2003 - American Cancer Society Postdoc Fellowship (ranked 1st in section prior to withdrawl)
2003 - National Institutes of Health NRSA Postdoctoral Fellowship (Declined)
2000 - Best Poster award at the 9th Annual "Egg to Organ" Symposium
1998-2001 - National Institutes of Health Genetics Training Grant
1998 - Henry Vilas Fellowship
1998 - National Science Foundation Predoctoral Fellowship Honorable Mention
1997-1998 - Wisconsin Alumni Research Foundation Fellowship
1993-1997 - W.R. Hotchkiss Foundation Scholarship
GRANT SUPPORT:
Research:
2008 - Margaret and Herman Sokol Endowment for Faculty and Graduate Student Research Projects in the Sciences, Office of the Vice President for Research and the Horace H. Rackham School of Graduate Studies ($4000)
2008 - 2010 Alfred P. Sloan Research Fellowship ($50,000)
2008 - 2011 National Research Service Award National Institutes of Health [1 F32 GM083513-0]
(Postdoctoral fellowship for Dr. Jonathan Gruber)
"Investigating compensatory mechanisms for gene expression in the yeast genome" Sponsor, ($141,318)
2007-2010 - National Science Foundation [DEB-0640485]
“Genetic basis of pigmentation evolution in Drosophila”, P.I. ($450,000)
2007 - REU supplement ($6000)
2008 - REU supplement ($6000)
2007-2009 - March of Dimes Basil O’Connor Starter Scholar Research award [5-FY07-181]
“The genetic basis of abnormal gene expression”, P.I. ($150,000)
2006-2007 - Rackham Graduate School (University of Michigan) [G005283]
“Genomic sources of altered gene expression”, P.I. ($15,000)
2006 - Whitaker II award, Department of Ecology and Evolutionary Biology, (University of Michigan), P.I. ($300)
Teaching:
2007-2008 - CRLT Large Lecture Course Grant (U. Michigan), co-PI ($22,500)
“Energizing Genetics: Incorporating active and cooperative learning into a large lecture course”
2006 - LSA “Teaching with technology” mini-grant (University of Michigan), P.I. ($2,000) “Presenting Interactive Lectures Using a Tablet P
PUBLICATIONS:
Polaczyk, P.J., R. Gasparini, and G. Gibson. 1998. Naturally occurring genetic variation affects Drosophila photoreceptor determination. Development. Genes & Evolution 207:462-470.
Cover Article
Halder G. H., P. J. Polaczyk, M.E. Kraus, A. Hudson, J. Kim, A. Laughon, and S.B. Carrol. 1998. The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in response to signaling proteins. Genes & Development 12:3900-3909.
Co-first authorship
Wittkopp, P.J., J.R. True, and S.B. Carroll. 2002. Reciprocal functions of the Drosophila Yellow and Ebony proteins in the development and evolution of pigment patterns. Development 129:1849-1858.
Cover article
Radovic, A, P.J. Wittkopp, A.D. Long, and M.D. Drapeau. 2002. Immunohistochemical colocalization of Yellow and male-specific Fruitless in Drosophila melanogaster neuroblasts. Biochemical and Biophysical Research Communications 293:1262-1264.
Wittkopp, P.J., K. Vaccaro and S.B. Carroll. 2002. Evolution of yellow gene regulation and pigmentation patterns in Drosophila. Current Biology 12:1547-1556.
Cover article
Drapeau, M.D., A. Radovic, P.J. Wittkopp, and A. Long. 2003. A gene necessary for normal male courtship, yellow, acts downstream of fruitless in the Drosophila melanogaster larval brain. J. of Neurobiology 55:53-72.
Wittkopp, P.J, B.L. Williams, J.E. Selegue, and S.B. Carroll. 2003. Drosophila pigmentation evolution: divergent genotypes underlying convergent phenotypes. Proc Natl Acad Sci U.S.A. 100:1808-1813
Featured in Nature Reviews Genetics Research Highlights section, April 2003
Wittkopp, P.J., S.B. Carroll, and A. Kopp. 2003. Evolution in Black and White: Genetic control of pigment patterns in Drosophila. Trends in Genetics 19:495-504.
Cover article
Wittkopp, P.J.*, Haerum, B.K. and A.G. Clark. 2004. Evolutionary divergence of cis and trans gene regulation. Nature 430: 85-88.
Selected by Faculty of 1000
Featured in Briefings in Bioinformatics 5, 370-377
*corresponding author
Gompel, N, B. Prud’homme, P.J. Wittkopp, V.A. Kassner, and S.B. Carroll. 2005. Chance caught on the wing: cis-regulatory evolution and the origin of pigment patterns in Drosophila. Nature 433:481-487.
Featured in 2005 Breakthrough of the year: Evolution in action, Science 310, 1878-1879
News and Views by Brakefield and French, Nature 433, 466-467
Selected by Faculty of 1000
Wittkopp, P.J. 2005. Genomic sources of regulatory variation in cis and in trans. Cellular and Molecular Life Sciences 62:1779-83.
Landry, C.R, P.J. Wittkopp, C. Taubes, J.M. Ranz, A.G. Clark, and D.L. Hartl. 2005. Compensatory cis-trans regulation and dysregulation of gene expression in hybrids between species. Genetics 171:1813-1822.
Selected by Faculty of 1000
Wittkopp, P.J. 2006. Evolution of cis-regulatory sequence and function in diptera. Heredity 97:139-147
Invited, Evolution and Development (EvoDevo) special issue
Wittkopp, P.J.,* B.K. Haerum, and A.G. Clark. 2006. Parent-of-origin effects on mRNA levels in Drosophila melanogaster are not caused by genomic imprinting. Genetics 173:1817-1821.
*corresponding author
Fay, J.C. and P.J. Wittkopp. 2007. Evaluating the role of natural selection in the evolution of gene regulation. Heredity 100: 191-199
Wittkopp, P.J. 2007. Variable gene expression in eukaryotes: a network perspective. Journal of Experimental Biology 210: 1567-1575.
Davis, G.K., D. Srinivasan, P.J. Wittkopp and D.L. Stern. 2007. The function and regulation of Ultrabithorax in the legs of Drosophila melanogaster. Developmental Biology 308:621-631.
Kohn, M.H. and P.J. Wittkopp. 2007. Annotating ebony on the fly. Molecular Ecology 16:2831-3.
Invited “News and Views”, non-peer reviewed
Wittkopp, P.J. 2007. Evolutionary genetics: how flies get naked. Current Biology 17:R881-3.
Invited “Dispatch”, non-peer reviewed
Wittkopp, P.J.*, B.K. Haerum, and A.G. Clark. 2008. Genetic basis of regulatory variation within and between Drosophila species. Nature Genetics 40:346-50.
Selected by Faculty of 1000
*corresponding author
Wittkopp, P.J.* B.K. Haerum, and A.G. Clark. 2008. Independent effects of cis- and trans-regulatory variation on gene expression in Drosophila melanogaster. Genetics 178:1831-5.
*corresponding author
Wittkopp, P.J. and P. Beldade. 2008. Development and evolution of insect pigmentation: genetic mechanisms and the potential consequences of pleiotropy. Seminars in Cell and Developmental Biology 20:65-71.
Invited, Pigment Cell Development special issue
Wittkopp, P.J.*, G. Smith-Winberry, L.L. Arnold, E. M. Thompson. 2008. Local adaptation for body color in Drosophila americana, Submitted.
*corresponding author
(undergraduate co-authors in italics) |
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